Aerosol Inhalation: Recent Research Frontiers: Proceedings by Morton Lippmann Ph.D. (auth.), J. C. M. Marijnissen, L.

By Morton Lippmann Ph.D. (auth.), J. C. M. Marijnissen, L. Gradoń (eds.)

A workforce of hugely esteemed aerosol scientists - physicists, chemists, biologists and toxicologists - met in Warsaw in September, 1995, with the intention to speak about the most recent advancements within the box of aerosol overall healthiness matters, together with inhalation, lung shipping and deposition. the connection of those topics with the surroundings was once additionally addressed.
This booklet includes the court cases of the Workshop and in addition files the resultant panel discussions.
topic Index included.

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Additional resources for Aerosol Inhalation: Recent Research Frontiers: Proceedings of the International Workshop on Aerosol Inhalation, Lung Transport, Deposition and the Relation to the Environment: Recent Research Frontiers, Warsaw, Poland, September 14–16, 1995

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Int. J. Epidemiol. ,Jr. Health Perspect. 41 (1981) 255 25 Environ. A Mechanistic Approach to Assessing the Lung Cancer Risk of Diesel Exhaust and Carbon Black Roger O. McClellan Chemical Industry Institute of Toxicology Research Triangle Park, NC, USA Telephone: (919) 558-1202 Fax: (919) 558-1400 27 J. C. M. Marijnissen and L. ). Aerosol Inhalation: Recent Research Frontiers. 27-77. © 1996 Kluwer Academic Publishers. Abstract Diesel exhaust soot particles, consisting principally of a carbonaceous core and absorbed organic compounds, are ubiquitous contaminants of the environment because of the widespread use of diesel engines.

One issue relates to the modulation of reactive oxygen species, cytokines, growth factors, and proteases. , 1996). For both carbon black and diesel soot particles, the process begins when the quantity of particles deposited and retained exceeds the normal protective capacity of the lung. I use the phrase quantity of particles in a broad sense, not being specific as to the particle metric that is most appropriate. The role of particle mass has been noted by Morrow (1988, 1994), while Driscoll (1996) and Oberd6rster (1996) both note the close correlation between particle surface area and lung tumor induction.

Fibrosis +++ + + ? Mutations +++ ? ? Lung cancer +++ +/- 44 ? +>- Ul Cytoklnes / Growth factors Proteases I, Fibrosis Deposition ~ '" "'-,-• ~epqir 00 Promotion , J protooncogenes ___ <> 8~p I tumor Inactivation of prOgreSSiOn' supressor genes / I JOn \ Malignant tumor Preneoplastic lesion Mutation~. -/ Organic chemicals -----...... / \ ~\~ "'UNIQUE "'- High-level exposure From HEI (1995). r I Hyperplasia" t , / b·~ ~ species Diesel exhaust Particulate matter Reactive - . oxygen _ _ _ I'~~ Carbon black • Inflammation Macrophage Clearance Limited deposition Low-level exposure Effective clearance Absence of injury and lung tumorigenesis -I» a- Mechanisms ~ DOSE Mechanisms ~ RESPONSE Inflammation Sequestration of particles relationships.

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