Alternatives to Animal Testing by Michael Balls, Roy M. Harrison, Ronald E. Hester

By Michael Balls, Roy M. Harrison, Ronald E. Hester

Animal experimentation has lengthy been a debatable factor, with impassioned arguments on each side of the talk. more and more it has turn into extra expedient and possible to improve new equipment that keep away from using animals. there's contract on each side that relief and refinement of experiments on animals might be a tremendous target for the industries involved.Alternatives to Animal trying out, written through top specialists within the box, discusses the problems concerned and techniques that may be taken. themes comprise: the protection assessment of chemical compounds; foreign validation and boundaries to the validation of other assessments; in vitro checking out for endocrine disruptors; clever techniques to protection review of chemical substances; substitute exams and the regulatory framework.The publication presents an up to date dialogue of the present country of improvement of choices to animal checking out and is perfect for execs and teachers within the box. it will even be of use for graduate scholars wishing to pursue a occupation within the pharmaceutical and cosmetics industries.

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Acute toxicity is divided into four classes: not classified, harmful, toxic and very toxic, on the basis of the dose at which effects are seen. Classification on grounds of skin and eye irritancy includes three classes: not classified, irritant and corrosive/severe irritant. Likewise classification on grounds of repeated dose toxicity includes three classes: not classified, harmful and toxic. Other effects (mutagenicity, carcinogenicity and reproductive toxicity) are classified on grounds of nature and quality of information, with category 1 requiring evidence in humans, category 2 good evidence in animals and category 3 limited evidence.

9 The OECD In 1996, the OECD secretariat worked closely with ECVAM and ICCVAM to agree an internationally acceptable set of validation criteria and principles,16 then, in 1998, set out to produce a guidance document for its member countries. However, this appears to have been overtaken by events, when pressure from certain regulatory authorities induced the OECD secretariat to organise validation studies on animal tests for identifying potential endocrine disruptors, in ways, which conflicted with the previously agreed criteria and principles.

G. to the nervous and immune systems) and multi-faceted 46 Michael Balls unnecessary, because it is inconceivable that the minimum toxic dose could ever be experienced in real life. 6 This entails selecting testing requirements specifically with regard to the likely expected exposure to the new chemical. In some cases, where the prospective exposure of the new chemical is extremely low, it might be deemed unnecessary for any animal tests to be performed at all. A more realistic approach to risk assessment in general, which would require less testing and therefore fewer animals and less expenditure, would be to assess likely exposure levels as the first step (Figure 7).

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